12/31/2023 0 Comments Hep b transmission to babyThrough all these efforts, we expect to meet the global goal of eliminating HBV infection by 2030. We have also adopted short-term antiviral treatments such as tenofovir 300 mg daily in the third trimester for highly viremic mothers and reduced the perinatal infection rates from 10.7 to 1.5%. To closely control perinatal HBV infection, we have administered hepatitis B immunoglobulin immediately after birth and checked the serum level of HBsAg and anti-HBs in high-risk babies born to HBsAg-seropositive mothers, irrespective of their HBeAg status, since July 2019. The HBsAg- and HBeAg-seropositive rate in pregnant women declined from 13.4% and 6.4% in 1984–1985 to 5.9% and 1.0% in 2016, respectively. Furthermore, we have performed a maternal HBV screening program during pregnancy since 1984, with the screening rate peaked at 93% in 2012. The incidence of hepatocellular carcinoma in children aged 6–9 years significantly declined from 0.52 to 0.13 per 100,000 children born before and after 1984, respectively. ![]() The prevalence of Hepatitis B surface antigen (HBsAg) decreased from 9.8% in pre-vaccinated period in 1984 to 0.5% in the vaccinated cohort in 2014. The three-dose HBV vaccine completion rate reached 98.1% in 2018. The first nationwide universal HBV vaccination program was launched in Taiwan in July 1984. In Taiwan, many important preventive interventions have been implemented to block the perinatal transmission of HBV in the past 35 years. Most infants infected by mother-to-infant HBV transmission become chronic carriers. Chronic hepatitis B viral (HBV) infection remains a major health threat, especially in high-prevalence areas.
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